I remember when I first starting taking anti-depressants and anti-anxiety medication that I was told I couldn’t eat grapefruit anymore. While this didn’t leave me suicidal, it certainly puzzled me then as it does now.
So in the interest of the depressed grapefruit lovers everywhere, here are a few articles that examine the issue:
Basically grapefruit has a bad interaction with a drug metabolizing enzyme called the CYP 3A4 enzyme. It makes it so that effectiveness of certain medications is drastically reduced.
Why grapefruits and not other citrus? I don’t know. But apparently, depression and grapefruit don’t mix.